Dr. Isaac Njangiru Profile

   Name of Staff: Dr. Isaac Njangiru

   Designation/Rank: Senior Technologist I

   Department: Chemistry and Biochemistry

   School: Science and Applied Technology

   Email:  injangiru@laikipia.ac.ke

         

PERSONAL DETAILS

A    Educational Background/Qualification

  1. PhD in Pharmaceutical Sciences, University of Szeged, Hungary (2024)
  2. Master of Science in Medical Biochemistry, Kenyatta University, Kenya (2017)
  3. Bachelor of Science in Biochemistry, Moi University, Kenya (2009)
  4. Diploma in Analytical Chemistry, Kabete Technical Training Institute (2002)

B   Brief Auto-biography of the Faculty/Staff

Dr. Njangiru is an accomplished scientist specializing in anticancer drug development. He earned his PhD in Pharmaceutical Sciences in 2024 from the University of Szeged, Hungary, where his research focused on novel approaches to combat cervical cancer. Dr. Njangiru holds a Master of Science in Medical Biochemistry (2017) from Kenyatta University, Kenya, and a Bachelor of Science in Biochemistry (2009) from Moi University. With a strong foundation in biochemistry and extensive expertise in medical research, he is passionate about advancing innovative therapies to improve global health outcomes. His academic journey reflects a commitment to excellence and a dedication to making meaningful contributions to the field of pharmaceutical sciences.

C   Areas of Specialization

  1. Pharmacology and Bio pharmacy
  2. Pharmacokinetics
  3. Medical Biochemistry

D   Research Interest

  1. Anticancer Drug Development
  2. Natural Products and Medicinal Chemistry
  3. Translational Research
  4. Nanomedicine in Oncology
  5. Molecular Biology and Genomics in Cancer

E    Selected Publications

  1. Njangiru, I. K., Bózsity-Faragó, N., Resch, V. E., Paragi, G., Frank, É., Balogh, G. T., ... & Minorics, R. (2024). A Novel 2-Methoxyestradiol Derivative: Disrupting Mitosis Inhibiting Cell Motility and Inducing Apoptosis in HeLa Cells In Vitro. Pharmaceutics. doi.org/10.3390/pharmaceutics16050622
  2. Le, T. M., Njangiru, I. K., Vincze, A., Zupkó, I., Balogh, G. T., & Szakonyi, Z. (2024). Synthesis and medicinal chemical characterisation of antiproliferative O, N-functionalised isopulegol derivatives. RSC advances. DOI: 10.1039/D4RA03467H
  3. Molnár, B., Kinyua, N. I., Mótyán, G., Leits, P., Zupkó, I., Minorics, R., ... & Frank, É. (2022). Regioselective synthesis, physicochemical properties and anticancer activity of 2-aminomethylated estrone derivatives. The Journal of Steroid Biochemistry and Molecular Biology. doi.org/10.1016/j.jsbmb.2022.106064
  4. Muhoro, A. M., Kosgei, J. J., Njangiru, I. K., Rasaki, L. A., & Farkas, E. É. (2024). Potential of Cladonia Foliacea Extract as an Oral Toxic Insecticide Against Adult Anopheles Gambiae, Malaria Vector in Western Kenya. Acta Botanica Hungarica. doi.org/10.1556/034.66.2024.3-4.7
  5. Muhoro, A. M., Ochomo, E. O., Kinyua, I. N., Kosgei, J. J., Rasaki, L. A., & Farkas, E. (2024). A study on the effectiveness of (+)-usnic acid as oral toxic sugar bait against adult male and female Anopheles gambiae. Malaria Journal. doi.org/10.1186/s12936-024-05141-4
  6. Tayeb, B. A., Njangiru, I. K., & Minorics, R. (2024). Beyond boundaries: Neuroprotective effects of steroids and ecdysteroids in SH‐SY5Y cells‐A systematic review. Neuroprotection. . doi.org/10.1002/nep3.37
  7. Tayeb, B. A., Osman, A. A., & Njangiru, I. K. (2024). Liquid biopsy biomarkers in breast cancer: An overview of systematic reviews. Clinica Chimica Acta. doi.org/10.1016/j.cca.2024.120063
  8. Kimani, N. L., Njangiru, I. K., Njagi, E. N. M., & Orinda, G. O. (2017). Antidiabetic Activity of Administration of Aqueous Extract of Berberis holstii. Journal of Diabetes Metabolism. doi: 10.4172/2155-6156.1000774
  9. Gitimu, R. M., Njangiru, I. K., & Njagi, E. N. M. (2017). Need for reference ranges for liver function tests in infants and children from Taita Taveta County, Kenya. Journal of Clinical Chemistry and Laboratory Medicine.
  10. Njangiru, I. K., Gitonga, N. Z., & Njagi, E. M. (2019). Hypoglycemic Potential and Safety of Aqueous Extract of Aspilia Mossambicensis in Alloxanized Diabetic Mice. Journal of Medical Research and Health Sciences. doi.org/10.15520/jmrhs.v2i3.38
  11. Njangiru, I. K. (2019). Bioscreening for Hypoglycemic Potential of Aqueous Extract of Tridax Procumbens in Mice Model. Journal of Medical Research and Health Sciences. doi.org/10.15520/jmrhs.v2i10.121
  12. Kimani, N. L., Njangiru, I. K., Njagi, E. N., & Orinda, G. O. (2017). Antidiabetic activity of administration of aqueous extract of Berberis holstii. doi: 10.4172/2155-6156.1000774.
  13. Njangiru, I. K., & Njeri, L. K. (2017). Effects of Oral Administration of Aqueous Extract of Tridax Procumbens on Body Organs and Hematological Parameters. International Journal of Contemporary Research and Review. doi.org/10.15520/ijcrr/2017/8/04/164.

F   Scholarly Presentations at Conferences/Workshops/Seminars

  1. 2024: Oral Presentation; Impact of a Novel 2-Methoxyestradiol Analog on Mitosis, Cell Motility and Apoptosis on Hela Cells In Vitro’’, Congressus Pharmaceuticus Hungaricus XVII and EUFEPS Annual Meeting, Hungary, May 23, 2024.
  2. 2023: Oral Presentation; ’Antineoplastic activity and pharmacokinetic attributes of 2-aminomethylated estrone derivatives on selected gynecological cancer cell lines’’, Steroid and Terpenoid Chemistry Working Committee of the Hungarian Academy of Sciences, Hungary, November 23, 2023.
  3. 2023: Oral Presentation; ‘Antitumor Efficacy and Pharmacokinetic Characteristics Of 2- Aminomethylated Analogues of Estrone Investigated on Cancer Cell Lines Originating from The Female Reproductive System In Vitro’’, XXVI Spring Wind Conference 2023; Miskolc-Egyetemváros, Hungary, May 5––7, 2023.
  4. 2022: Oral Presentation; ’Antineoplastic activity and pharmacokinetic attributes of 2-aminomethylated estrone derivatives on selected gynecological cancer cell lines’’, Steroid and Terpenoid Chemistry Working Committee of the Hungarian Academy of Sciences, Hungary, November 28, 2022.
  5. 2021: Poster Presentation; ‘’In vitro anti-proliferative activity and pharmacokinetic attributes of 2-aminomethylated estrone analogues on cancer cell lines of gynecological origin’’, 11th ISCTICO – HUPHAR – IUPHAR – CONFERENCE, PÉCS, HUNGARY, OCTOBER 27-30, 2021.
  6. 2017, Kenyatta University, Kenya. MSc. Thesis oral defense. “Pharmacological and Toxicological Study of Five Medicinal Plants Traditionally Used in Management of Diabetes in Nakuru County Kenya.’’ 13th June, 2017.
  7. 2016, Kenyatta University, Kenya. Departmental postgraduate presentations. “Pharmacological and Toxicological Study of Five Medicinal Plants Traditionally Used in Management of Diabetes in Nakuru County Kenya.’’ 21st AUG, 2016.
  8. 2016, Laikipia University, Nyahururu Kenya. 3rd international conference: Enhanced utilization of research, science and technology for innovation and sustainable development in Africa. 24th -27th June, 2016.
  9. 2014. Laikipia University, Kenya. School of Science monthly seminar. “Chemical safety, Security and waste Management.’’ 20th Sep, 2014.
  10. 2014, Laikipia University, Nyahururu Kenya. 2nd international conference: Enhanced utilization of research, science and technology for innovation and sustainable development in Africa. 20th -23rd May, 2014.
  11. 2012, Laikipia University, Nyahururu Kenya. 2nd international conference: Enhanced utilization of research, science and technology for innovation and sustainable development in Africa. 20th -23rd June, 2012.

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